Combined Radiotherapy and Immune Checkpoint Blockade Therapy for Breast Cancer

Treatment with checkpoint inhibitors have shown durable responses in a number of solid tumors, including melanoma, lung, and renal cell carcinoma. However, most breast cancers are resistant to monotherapy with checkpoint inhibitors. Radiotherapy has been shown to have a number of immunostimulatory effects, including priming the immune system, recruiting immune cells to the tumor environment, and altering the immunosuppressive effects of the tumor microenvironment. Radiotherapy therefore represents a promising adjuvant therapy to checkpoint blockade in breast cancer.

http://ift.tt/2r5pwXS