Genioglossus muscle activity during sniff and reverse sniff in healthy men

New Findings

What is the central question of this study?

Maximal sniff nasal inspiratory and reverse sniff nasal expiratory pressures are measured as inspiratory and expiratory muscle strength, respectively. Is the genioglossus muscle activated during short maximal inspiratory and expiratory efforts through the nose?

What is the main finding and its importance?

Genioglossus muscle activity occurred with inspiratory muscle activity during a maximal sniff and with expiratory muscle activity during a maximal reverse sniff. These results indicate that genioglossus muscle activity is closely related to the generation of maximal sniff nasal inspiratory and reverse sniff nasal expiratory pressures.

Abstract

Maximal sniff nasal inspiratory pressure (SNIP_max) is widely used to assess inspiratory muscle strength. The sniff nasal inspiratory pressure (SNIP) is lower in patients with neuromuscular disease with bulbar involvement compared with those without, possibly owing to impaired upper airway muscle function. However, the degree to which the genioglossus (GG) muscle, one of the upper airway muscles, is activated during inspiratory and expiratory efforts through the nose remains unclear. Therefore, we examined GG activity during short and sharp inspiratory and expiratory efforts through the nose, i.e. sniff and reverse sniff manoeuvres. In eight normal young subjects, we inserted fine wire electrodes into the GG muscle, parasternal intercostal and scalene (inspiratory) muscles and transversus abdominis (expiratory) muscle. We assessed EMG activity of each muscle and measured SNIP and reverse sniff nasal expiratory pressure (RSNEP) during sniffs and reverse sniffs from low to high intensities in the sitting position. The highest SNIP and RSNEP were analysed as SNIP_max and maximal RSNEP (RSNEP_max), respectively. In each subject, GG EMG activity increased linearly with increasing SNIP and RSNEP. The SNIP_max and RSNEP_max were −85.1 ± 15.9 and 83.2 ± 24.2 cmH₂O, respectively. Genioglossus EMG activity varied with EMG activity of the parasternal intercostal and scalene muscles during generation of SNIP_max and with EMG activity of the transversus abdominis muscle during RSNEP_max. Genioglossus EMG activity during generation of SNIP_max was higher than during RSNEP_max (62.9 ± 31.1% EMG of SNIP_max, P = 0.012). These results suggested that GG activity was closely related to the generation of both SNIP_max and RSNEP_max.

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