Influenza A M2 Channel Clustering at High Protein to Lipid Ratios: Viral Budding Implications

Protein dynamics in crowded environments is important for understanding protein functions in vivo and is especially relevant for membrane proteins due to the roles of protein-protein interactions in membrane protein functions and their regulation. Here, using solid-state NMR spectroscopy in combination with coarse-grained molecular dynamics simulations, we report that the rotational correlation time for the transmembrane domain of the Influenza A M2 proton channel in lipid bilayers increases dramatically at an elevated protein-to-lipid ratio.

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