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We thank Drs Gracie and Ford for their interest in our recent article.1 We appreciate their comments and discussion of the recent data from the Inflammatory Bowel South-Eastern Norway study,2 highlighting both the clinical significance of functional gastrointestinal symptoms in inflammatory bowel disease (IBD) as well as the critical importance of investigating noninflammatory mechanisms in this patient population. Findings further raise the question of whether histologic remission is a sufficient therapeutic target in IBD patients with persistent symptoms.

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