Physical Properties of Bacterial Outer Membrane Models: Neutron Reflectometry & Molecular Simulation

The outer membrane (OM) of Gram-negative bacteria is an asymmetric bilayer having phospholipids in the inner leaflet and lipopolysaccharides (LPS) in the outer leaflet. This unique asymmetry and the complex carbohydrates in LPS make it a daunting task to study the asymmetrical OM structure and dynamics, its interactions with outer membrane proteins, as well as its roles in translocation of substrates including antibiotics. In this study, we combine neutron reflectometry and molecular simulation to explore physical properties of OM mimetics.

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