Synaptobrevin-2 C-terminal Flexible Region Regulates the Discharge of Catecholamine Through the Fusion Pore

The discharge of catecholamine molecules through the fusion pore is a regulated process, and understanding the role of the SNARE proteins during this process has been of great interest. These proteins facilitate the formation of the fusion pore, but it has been unclear whether their transmembrane domains regulate the flux of discharged catecholamines through direct interactions. Here, it is shown, using mutagenesis studies, that the transmembrane domain of the vesicular SNARE protein, synaptobrevin-2, does not directly interact with the discharged catecholamine, however it is suggested that synaptobrevin-2 transmembrane domain indirectly modulates the flux of catecholamine by interacting with the vesicle membrane.

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