De Novo PITX1 Expression Controls Bi-Stable Transcriptional Circuits to Govern Self-Renewal and Differentiation in Squamous Cell Carcinoma

Self-renewal and differentiation programs are critical determinants of tissue homeostasis and tumor growth. Sastre-Perona et al. identify a cancer-specific PITX1-, SOX2-, and TRP63-dependent transcriptional feed-forward circuit that governs self-renewal and squamous cell carcinoma growth as it inhibits KLF4-dependent differentiation.

http://bit.ly/2Rr0a25