EGFR-Aurka Signaling Rescues Polarity and Regeneration Defects in Dystrophin-Deficient Muscle Stem Cells by Increasing Asymmetric Divisions

Wang et al. found that EGFR-Aurka signaling in muscle stem cells acts to direct apicobasally oriented mitoses and asymmetric cell division. EGF treatment rescues the reduction of asymmetric divisions in dystrophin-deficient satellite cells in mdx mice, resulting in increased numbers of progenitors and enhanced regeneration.

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