Single-channel resolution of the interaction between C-terminal CaV1.3 isoforms and calmodulin

Voltage-dependent calcium CaV1.3 channels are involved in the control of cellular excitability and pacemaking in neuronal, cardiac and sensory cells. Various proteins interact with the alternatively spliced channel C-terminus regulating gating of CaV1.3 channels. Binding of a regulatory calcium-binding protein calmodulin (CaM) to the proximal C-terminus leads to the boosting of channel activity and promotes calcium-dependent inactivation (CDI). The C-terminal modulator domain (CTM) of CaV1.3 channels can interfere with the CaM binding, thereby inhibiting channel activity and CDI.

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