Comparative study of oxidative status in blood of asthmatic patients

Abstract

Bronchial asthma (BA) is a chronic inflammatory lungs disease, resulting in an airflow restriction, hyperactivity, and airway remodeling. The aim of present study is to investigate and compare the oxidative stress levels in blood of asthmatic patients differ in the disease control degree. In the current study were included 30 patients with bronchial asthma and 24 healthy volunteers. Patients were diagnosed with BA with allergic component longer than 1 year. For this purpose were explored the reactive oxygen species (ROS) and reactive nitrogen species (RNS), final products of lipids and proteins. Also, were studied the relationship between oxidative stress parameters and C-reactive protein (CRP) as a marker of inflammation degree. By using the electron paramagnetic resonance (EPR) spin trapping technique, ongoing the real-time oxidative processes were confirmed in blood samples isolated from asthmatic patients differing in the disease control degree. Moreover, positive correlation was found between the levels of studied oxidative stress (OS) biomarkers and CRP as a marker of inflammation degree. The oxidative processes in real time were demonstrated in BA patients. The correlation analysis results confirm the development and maintenance of inflammatory processes in respiratory tract is associated with the oxidative and nitrosative stress.

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