The Effect of MATE1 Polymorphisms on Cisplatin Efficacy in the Treatment of Head and Neck Cancer

MATE1 (multidrug and toxin extrusion protein 1/SLC47A1) has an important role in the renal and biliary excretion of endogenous and exogenous organic cations including a number of therapeutic drugs. We recently reported that homozygosity for a single nucleotide polymorphism in MATE1 (rs2289669) (A/A) was independently protective for cisplatin-related ototoxicity in patients with head and neck squamous cell carcinoma (HNSCC) receiving cisplatin-based chemoradiation. To evaluate whether MATE1 A/A status had any effect on treatment efficacy we examined cancer outcomes in a subset of our patients expected to have a poorer prognosis.

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