What Measures Improve Reduction of Intussusception in Pediatric Patients?

Investigators included 6 randomized controlled trials with 822 patients for analysis. The addition of glucagon to liquid enema versus liquid enema alone did not improve the rate of successful reduction of intussusception.1,2 Studies comparing these 2 interventions did not report on numbers of children with bowel perforations or recurrent intussusception. Air or liquid enema with dexamethasone intramuscularly versus air or liquid enema alone resulted in no benefit in regard to successful reduction or incidence of bowel perforation, although it did result in decreased risk of recurrent intussusception (risk ratio 0.14; 95% confidence interval [CI] 0.03 to 0.60), with a number needed to treat for an additional beneficial outcome (NNTB) of 13.

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