Can a Negative High-Sensitivity Troponin Result Rapidly Rule Out Acute Myocardial Infarction?

Eleven studies were included, with a total of 9,241 patients. Overall acute myocardial infarction prevalence was 15.4%. Of the total included patient population, 30.6% were classified as being at low risk for acute myocardial infarction by a single negative hs-cTnT result and a nonischemic ECG result. Of these patients, 14 (0.5%) received a diagnosis of acute myocardial infarction. In 7 of these cases, the time between symptom onset and blood sampling was less than 3 hours. The pooled performance estimates for the primary and secondary outcomes of acute myocardial infarction and major adverse cardiac events are presented in the Table.

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