In vitro activity of Pexiganan and 10 comparator antimicrobials against 502 anaerobic isolates recovered from skin and skin-structure infections (SSSI). [PublishAheadOfPrint]

Pexiganan, a cationic peptide, exhibited a broad range of anti-anaerobic antimicrobial activity. MIC₉₀s were as follows: B. fragilis, 16 μg/ml; other Bacteroides fragilis group spp., 4 μg/ml; Prevotella and Fusobacterium spp., 32 μg/ml; and Porphyromonas spp., 64 μg/ml; P. acnes, 4 μg/ml; E. lenta and P. anaerobius, 32 μg/ml; other Gram-positive rods and cocci, 4 μg/ml; Clostridium perfringens, 128 μg/ml; and other clostridia, 256 μg/ml. Pexiganan cream shows potential as adjunctive therapy for SSSIs involving anaerobes.

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