LAG3+ Regulatory T Cells Restrain Interleukin-23-Producing CX3CR1+ Gut-Resident Macrophages during Group 3 Innate Lymphoid Cell-Driven Colitis

Treg cells control of tissue resident macrophages and ILC3 function has not been elucidated. Bauche et al. demonstrate that LAG-3+ Treg cells suppress the production of pro-inflammatory cytokines by CX3CR1+ macrophages and thereby inhibit ILC3-driven colitis.

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