Electron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer Immunization

Comprehensive epitope mapping is fundamental to understanding immune responses. Bianchi et al. applied electron microscopy to study polyclonal antibody responses in HIV-Env-immunized rabbits. Different antibody specificities were identified and followed over time, revealing the source of neutralization, a distinct class of antibodies, and a highly convergent structural evolution of the neutralizing antibodies.

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