Response:

We thank Dr Köker for his interest in our study, "Association between an increase in blood urea nitrogen at 24 hours and worse outcomes in acute nonvariceal upper GI bleeding."1 In his letter to the editor, the author notes that renal disease is an independent risk factor for upper GI bleeding (UGIB). Given that blood urea nitrogen (BUN) elevations are more likely to be seen in patients with renal disease, the author expresses concern that the findings of our study were driven by the patients with moderate or severe renal disease in our study sample.

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