Blood urea nitrogen increase is an expected finding in nonvariceal upper GI bleeding patients with underlying moderate or severe renal disease

In a recent article, Kumar et al1 studied the association between increased blood urea nitrogen (BUN) at 24 hours and outcomes in nonvariceal upper GI bleeding in a retrospective study design. The authors speculated that a BUN increase within 24 hours of admission could be a risk factor for worse outcomes, as observed in acute pancreatitis by Wu et al.2 Their study cohort included 357 patients. Of those, 320 (90%) experienced a decrease or no change in BUN, whereas 37 patients (10%) had an increase in BUN at 24 hours after admission.

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