Longitudinal evaluation of lung function in patients with advanced Non-small cell lung cancer treated with concurrent chemo-radiotherapy

This study prospectively evaluated how concurrent radiotherapy (CCRT), a common therapeutic course for lung cancer, affects pulmonary function tests (PFT) initially, throughout and after treatment. The longitudinal evaluation with PFT efficiently detected early changes in lung function after CCRT-induced damage; these changes are independent of the presence of symptoms. We document the longitudinal evaluation of lung function through PFTs and detected CCRT-induced damage before the appearance of clinical symptoms associated with CCRT lung toxicity.

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