Acute epithelial toxicity is prognostic for improved prostate cancer response to radiotherapy: a retrospective multi-centre cohort study

We hypothesised that increased early radiation toxicity, measured using specific subdomains, is associated with improved local control following prostate radiotherapy. We used a discovery cohort to select the specific subdomains of acute GU and GI toxicity most likely to represent epithelial damage, and subsequently confirmed in patients from 2 other institutions that acute toxicity significantly reduces late biochemical failure. This confirms there is a potential genetic link between acute radiation toxicity and cancer outcomes.

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