A Randomized Phase II Trial of Consolidation Chemotherapy after Preoperative Chemoradiation versus Chemoradiation alone for Locally Advanced Rectal Cancer: KCSG CO 14-03

Preoperative chemoradiation followed by 6-8 weeks of rest until total mesorectal excision is the standard of care in locally advanced rectal cancer. This randomized phase II study suggested pathologic downstaging could be marginally improved with consolidation chemotherapy after preoperative chemoradiation before total mesorectal excision.

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