Volume, Dose, and Fractionation Considerations for IMRT-based Re-Irradiation in Head and Neck Cancer: A Multi-Institution Analysis

For patients with squamous cell carcinoma of the head and neck undergoing re-irradiation with IMRT, doses ≥66 Gy may be associated with improved outcomes. Postoperatively, doses of 50-66 Gy appear adequate after removal of gross disease. Hyperfractionation and elective neck irradiation are not associated with an obvious benefit and may increase toxicity.

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