Corticosteroids in IgA Nephropathy

Corticosteroid use in patients with immunoglobulin A nephropathy (IgAN) remains controversial. The KDIGO (Kidney Disease: Improving Global Outcomes) guideline recommended use of renin-angiotensin-aldosterone system (RAAS) inhibitors as the initial approach, followed by a course of corticosteroids in patients with IgAN who have an estimated glomerular filtration rate (eGFR)>50mL/min/1.73m2 and proteinuria with protein excretion > 1g/d.1 The VALIGA (Validation Study of the Oxford Classification of IgAN) retrospective study2 and 2 randomized controlled trials (RCTs)3,4 reported that corticosteroids improved proteinuria and protected kidney function in the long term.

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