A prospective multicenter phase II trial of induction chemotherapy followed by bio-chemoradiotherapy for locally advanced recurrent nasopharyngeal carcinoma

In this phase II study, an intensive regimen, consisting of induction docetaxel, cisplatin and fluorouracil followed by weekly docetaxel and cetuximab in concurrence with intensity modulated radiotherapy was shown to be efficacious in treating advanced locally recurrent nasopharyngeal carcinoma. The 3-year progression-free and overall survival rates were 35.7% and 63.8%, respectively. The rate of severe late complication is similar to other contemporary studies employing IMRT.

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