Radiation Necrosis and White Matter Lesions in Pediatric Patients with Brain Tumors treated with Pencil Beam Scanning Proton Therapy

Limited clinical data in children treated with pencil beam scanning proton therapy for a brain tumor are available. We retrospectively analyzed our pediatric patients and reviewed magnetic resonance imaging changes after proton therapy, to assess the rate of radiation necrosis and white matter lesions. Overall, children treated with PBS proton therapy demonstrated a low prevalence of symptomatic radiation necrosis and white matter lesions, compared to similar cohorts treated with either proton or photon radiation therapy.

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