Chromosome-Mediated mcr-3 Variants in Aeromonas veronii from Chicken Meat [PublishAheadOfPrint]

Two adjacent colistin resistance gene variants, termed mcr-3.2 and mcr-3-like, were identified in the chromosome of an Aeromonas veronii isolated from retail chicken meat. The variants showed 95.20% and 84.19% nucleotide sequence identity, respectively, to mcr-3 from porcine Escherichia coli. Functional cloning indicated that only mcr-3.2 conferred polymyxin resistance in both E. coli and Aeromonas salmonicida. The mcr-3.2-mcr-3-like segment was also observed in other Aeromonas species, including A. media, A. caviae, and A. hydrophila.

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