Abstract Loss of protein homeostasis is a hallmark of the aging process. We and others have previously shown that maintenance of proteostasis is a shared characteristic of slowed-aging models. Rapamycin (Rap) exerts sex-specific effects on murine lifespan, but the combination of Rap with the anti-hyperglycemic drug metformin (Rap + Met) equally increases male and female mouse median lifespan. In the current investigation, we compare the effects of short-term (8 weeks) Rap and Rap...
Wed Aug 05, 2020 03:00
33 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human homeostasis These pubmed results were generated on 2020/08/05PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Wed Aug 05, 2020 16:13
114 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: human physiology These pubmed results were generated on 2020/08/05PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Wed Aug 05, 2020 14:58
2662 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2020/08/05PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Wed Aug 05, 2020 17:19
2662 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: medical science These pubmed results were generated on 2020/08/05PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Wed Aug 05, 2020 13:16
Scrape it all up. (Nadya Spetnitskaya via Unsplash/)A dough scraper is essential for the kneading process. This tool can capture rogue flour, press other ingredients into the mixture, and manipulate dough without getting it stuck to your hands. These versatile tools have dozens of other uses—their blades are excellent for not only cutting dough into portions, but also great for slicing other ingredients and produce, or cleaning up messes through, well, scraping.We’ve chosen some of our favorites.Bake...
06:12
Ancient valleys on Mars are similar to ones that exist around Devon Island in the Canadian Arctic Archipelago. Both on Earth and on Mars, valleys left by icy channels are distinctive because they can flow uphill, the researchers observed. (Grau Galofre/ASU/)The southern hemisphere of Mars contains hundreds of networks of valleys that have long puzzled geologists. They believe erosion from liquid water created these ancient depressions, which indicate that early Mars was a relatively warm place. But...
01:00
A fascination with the stars is part of our human nature, but studying them is a complex task. (Pexels/)The following is an excerpt adapted from The Last Stargazers: The Enduring Story of Astronomy’s Vanishing Explorers by Emily Levesque.“Have you tried turning it off and back on again?”This phrase, repeated by weary IT specialists the world over, had possibly never prompted such horror. First of all, it was one in the morning, and I was sitting in a chilly control room on top of the highest mountain...
Wed Aug 05, 2020 23:00
From left to right, the new earbuds, smartwatch, Note20, and S7 tablet. (Samsung/)Samsung announced a slew of new phones, wearables, and tablets in an event streamed from South Korea this morning. The presentation, called Unpacked, included plenty of talk about the new normal that the coronavirus pandemic has led to, and featured video of remote Samsung fans applauding in the background. In brief, it was a typical tech product unveiling during strange times.A bunch of latest-edition products headlined...
Wed Aug 05, 2020 21:55
These tips might not be as valuable as knowing how to build a fire, but they're close. (Matt Whitacre/Unsplash/)This story was originally featured on Field & Stream.Sometimes the best ideas are the simplest—which is certainly the case with this collection of outdoor tricks and gear hacks that readers have sent us over the years. In the next few weeks, we’ll be sharing our “greatest hits” of those reader tips, starting with this list of camping tips. From a toilet-paper protector to a modified...
Wed Aug 05, 2020 19:00
Neo Toky, the setting of the popular anime film <i>Akira</i>, is about to explode. (Neo Tokyo/)Frank Fuller is an adjunct professor of political science at Villanova University. This story was originally featured on The Conversation.At the end of Katsuhiro Otomo’s dystopian Japanese anime film Akira, a throbbing, white mass begins to envelop Neo-Tokyo. Eventually, its swirling winds engulf the metropolis, swallowing it whole and leaving a skeleton of a city in its wake.The atomic bombings...
Wed Aug 05, 2020 22:12
All the lights you'll need to read in the dark. (Awar Kurdish via Unsplash /)Any avid reader knows that squinting to see the words on a page is detrimental to the literary experience. A book light is the only way to go when it comes to combating darkness. Whether you need an extra boost of light on an airplane, can’t see in the dark while you’re waiting for the bus, or have a photosensitive sleeping partner, these little luminaries will let you open up your paperback anytime, anywhere. Sure, you...
Wed Aug 05, 2020 18:04
Sandals for your adventure. (Toa Heftiba via Unsplash/)In the past few years, sporty sandals have become more fashionable, and many have been designed in a larger range of fun colors. They’re also great for trips—why pack two sets of shoes when you might only need one? Whether you’re going on a tropical getaway, a camping trip, or just a walk around the corner to your favorite bodega, these stylish all-terrain sandals are a great choice.You can find them in every color of the rainbow. (Amazon/)Tevas...
Wed Aug 05, 2020 16:20
A place to plug in all your devices. (Amazon/)We’re all in the same situation: so many gadgets that are charged by a USB connection and not nearly enough ports to keep them charged. I’ve got my phone and mouse connected to my laptop, a number of controller chargers and external hard drives charging through my PC and gaming systems, and my bluetooth headphones and speakers plugged directly into a surge protector. I can never find a power block when I need to charge my Iphone. It’s chaos! Chaos, I...
Wed Aug 05, 2020 16:17
Founded in 2017, ClearMask makes transparent surgical masks that are FDA approved. Now it's turning its attention to pandemic equipment as well. (Courtesy of ClearMask/)Allysa Dittmar still remembers the day clearly. While undergoing a hospital procedure in 2017, the doctors, suited up in their surgical gowns and masks, asked her a number of pre-op questions. But she couldn’t understand their words or give them answers. Dittmar is deaf and relies on lip reading, sign language, and other visual cues...
Wed Aug 05, 2020 19:10
Related Articles Continuing nursing education: use of observational pain assessment tool for diagnosis and management of pain in critically ill patients following training through a social networking app versus lectures. BMC Med Educ. 2020 Aug 03;20(1):247 Authors: Deldar K, Froutan R, Sedaghat A, Mazlom SR Abstract BACKGROUND: Nursing staff training in using observational pain assessment tools is highly important to improve the assessment of...
Wed Aug 05, 2020 13:48
Related Articles Co-occurring mental illness, drug use, and medical multimorbidity among lesbian, gay, and bisexual middle-aged and older adults in the United States: a nationally representative study. BMC Public Health. 2020 Aug 04;20(1):1123 Authors: Han BH, Duncan DT, Arcila-Mesa M, Palamar JJ Abstract BACKGROUND: Older lesbian, gay, and bisexual (LGB) adults are an underserved and understudied population that experience specific health disparities....
Wed Aug 05, 2020 16:20
Related Articles Healthcare retention and clinical outcomes among adolescents living with HIV after transition from pediatric to adult care: a systematic review. BMC Public Health. 2020 Aug 03;20(1):1195 Authors: Ritchwood TD, Malo V, Jones C, Metzger IW, Atujuna M, Marcus R, Conserve DF, Handler L, Bekker LG Abstract BACKGROUND: Adolescents living with HIV (ALWH) who transition from pediatric to adult care face several challenges that increase...
Wed Aug 05, 2020 16:20
Related Articles Correction to: Implementation of nationwide screening of pregnant women for HTLV-1 infection in Japan: analysis of a repeated cross-sectional study. BMC Public Health. 2020 Aug 03;20(1):1196 Authors: Yonemoto N, Suzuki S, Sekizawa A, Hoshi S, Sagara Y, Itabashi K Abstract An amendment to this paper has been published and can be accessed via the original article. PMID: 32746803 [PubMed - in process]
Wed Aug 05, 2020 16:20
Related Articles Protocol for economic evaluation alongside the SHINE (Supporting Healthy Image, Nutrition and Exercise) cluster randomised controlled trial. BMJ Open. 2020 Aug 03;10(8):e038050 Authors: Brown V, Williams J, McGivern L, Sawyer S, Orellana L, Luo W, Hesketh KD, Wilfley DE, Moodie M Abstract INTRODUCTION: Limited evidence exists on the cost-effectiveness of interventions to prevent obesity and promote healthy body image in adolescents....
Wed Aug 05, 2020 13:13
Related Articles Workplace social capital and refraining from seeking medical care in Japanese employees: a 1-year prospective cohort study. BMJ Open. 2020 Aug 03;10(8):e036910 Authors: Inoue A, Tsutsumi A, Eguchi H, Kachi Y, Shimazu A, Miyaki K, Takahashi M, Kurioka S, Enta K, Kosugi Y, Totsuzaki T, Kawakami N Abstract OBJECTIVES: We examined the association of workplace social capital (WSC), including structural and cognitive dimensions, with...
Wed Aug 05, 2020 13:13
Related Articles Prevalence trends in non-alcoholic fatty liver disease at the global, regional and national levels, 1990-2017: a population-based observational study. BMJ Open. 2020 Aug 03;10(8):e036663 Authors: Ge X, Zheng L, Wang M, Du Y, Jiang J Abstract OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) is the leading cause of end-stage liver diseases worldwide. Understanding NAFLD prevalence and trends over time at the global, regional...
Wed Aug 05, 2020 13:13
Related Articles Methodological quality of meta-analyses indexed in PsycINFO: leads for enhancements: a meta-epidemiological study. BMJ Open. 2020 Aug 03;10(8):e036349 Authors: Leclercq V, Beaudart C, Ajamieh S, Tirelli E, Bruyère O Abstract OBJECTIVES: Meta-analyses (MAs) are often used because they are lauded to provide robust evidence that synthesises information from multiple studies. However, the validity of MA conclusions relies on the...
Wed Aug 05, 2020 13:13
Related Articles Exploring the factors that affect new graduates' transition from students to health professionals: a systematic integrative review protocol. BMJ Open. 2020 Aug 03;10(8):e033734 Authors: Opoku EN, Van Niekerk L, Jacobs-Nzuzi Khuabi LA Abstract INTRODUCTION: To become a competent health professional, the nature of new graduates' transition plays a fundamental role. The systematic integrative review will aim to identify the existing...
Wed Aug 05, 2020 13:13
Related Articles Effects of Simulated Microgravity on Muscle Stem Cells Activity. Cell Physiol Biochem. 2020 Aug 05;54(4):736-747 Authors: Tarantino U, Cariati I, Marini M, D'Arcangelo G, Tancredi V, Primavera M, Iundusi R, Gasbarra E, Scimeca M Abstract BACKGROUND/AIMS: The study of the effects of simulated microgravity on primary cultures of human satellite cells represents a reliable model for identifying the biomolecular processes involved...
Wed Aug 05, 2020 14:31
Related Articles Frail older adults show a distinct plasma microvesicle profile suggesting a prothrombotic and proinflammatory phenotype. J Cell Physiol. 2020 Aug 04;: Authors: Arauna D, Chiva-Blanch G, Padró T, Fuentes E, Palomo I, Badimon L Abstract In a global context of advanced aging, geriatric diseases such as frailty syndrome face challenges in the search for biomarkers and preventive strategies. Frailty has been associated with atherothrombotic...
Wed Aug 05, 2020 16:35
Related Articles Roles of BATF/JUN/IRF4 complex in tacrolimus mediated immunosuppression on Tfh cells in acute rejection after liver transplantation. J Cell Physiol. 2020 Aug 04;: Authors: Tang T, Xu T, Liu X, Yang T, Zhang L, Yang Z Abstract Rejection injury is a serious complication after liver transplantation (LTx). Tacrolimus (Tac) is a key immunosuppressive agent in the prevention of liver rejection after transplantation. The basic leucine...
Wed Aug 05, 2020 16:35
Related Articles Towards analyzing the potential of exosomes to deliver microRNA therapeutics. J Cell Physiol. 2020 Aug 04;: Authors: Giassafaki LN, Siqueira S, Panteris E, Psatha K, Chatzopoulou F, Aivaliotis M, Tzimagiorgis G, Müllertz A, Fatouros DG, Vizirianakis IS Abstract Exosome selectivity mechanisms underlying exosome-target cell interactions and the specific traits affecting their capability to communicate still remain unclear. Moreover,...
Wed Aug 05, 2020 16:35
Related Articles Narrow H3K4me2 is required for chicken PGC formation. J Cell Physiol. 2020 Aug 04;: Authors: Zhang C, Zuo Q, Wang M, Chen H, He N, Jin J, Li T, Jiang J, Yuan X, Li J, Shi X, Zhang M, Bai H, Zhang Y, Xu Q, Cui H, Chang G, Song J, Sun H, Zhang Y, Chen G, Li B Abstract The development of primordial germ cells (PGCs) undergoes epigenetic modifications. The study of histone methylation in regulating PGCs is beneficial to understand...
Wed Aug 05, 2020 16:35
Related Articles Light-emitting diode irradiation induces AKT/mTOR-mediated apoptosis in human pancreatic cancer cells and xenograft mouse model. J Cell Physiol. 2020 Aug 04;: Authors: Kim YM, Ko SH, Shin YI, Kim Y, Kim T, Jung J, Lee SY, Kim NG, Park KJ, Ryu JH Abstract The beneficial effects of light-emitting diode (LED) irradiation have been reported in various pathologies, including cancer. However, its effect in pancreatic cancer cells...
Wed Aug 05, 2020 16:35
Related Articles YEATS2 is a target of HIF1α and promotes pancreatic cancer cell proliferation and migration. J Cell Physiol. 2020 Aug 04;: Authors: Zeng Z, Lei S, He Z, Chen T, Jiang J Abstract Hypoxia is involved in the development of pancreatic cancer (PC). The responses of hypoxia-associated genes and their regulated mechanisms are largely unknown. In this study, through bioinformatic analysis and quantitative real-time polymerase chain...
Wed Aug 05, 2020 16:35
Related Articles Eat Your Carrots! β-Carotene and Cholesterol Homeostasis. J Nutr. 2020 Aug 01;150(8):2003-2005 Authors: von Lintig J PMID: 32747944 [PubMed - in process]
Wed Aug 05, 2020 14:14
Related Articles Increased lipopolysaccharide-induced hypothermia in neurogenic hypertension is caused by reduced hypothalamic PGE2 production and increased heat loss. J Physiol. 2020 Aug 04;: Authors: Amorim MR, Moreira DA, Santos BM, Ferrari GD, Nogueira JE, de Deus JL, Alberici LC, Branco LGS Abstract KEY POINTS: The mechanisms involved in hypothermia and fever during systemic inflammation (SI) remains largely unknown. Our data support the...
Wed Aug 05, 2020 15:18
Related Articles Building of AMPA-type glutamate receptors in the ER and its implication for excitatory neurotransmission. J Physiol. 2020 Aug 04;: Authors: Schwenk J, Fakler B Abstract AMPA-type glutamate receptors (AMPARs), the key elements of fast excitatory neurotransmission in the brain, are receptor ion channels whose core is assembled from pore-forming and three distinct types of auxiliary subunits. While it is well established that this...
Wed Aug 05, 2020 15:18
Related Articles Fighting the intergenerational cycle of obesity with maternal exercise. J Physiol. 2020 Aug 04;: Authors: Muhlhausler B PMID: 32749706 [PubMed - as supplied by publisher]
Wed Aug 05, 2020 15:18
Related Articles Unitary sources say: It is inhibition! J Physiol. 2020 Jul 21;: Authors: Sinha M, Narayanan R PMID: 32748395 [PubMed - as supplied by publisher]
Wed Aug 05, 2020 15:18
54 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Proc Natl Acad Sci U S A"[jour] These pubmed results were generated on 2020/08/05PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Wed Aug 05, 2020 17:26
54 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Proc Natl Acad Sci U S A"[jour] These pubmed results were generated on 2020/08/05PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Wed Aug 05, 2020 13:29
Πώς «θρέφουν» την άνοια οι ανισότητες και ποιοι είναι οι παράγοντες κινδύνου που αν «αποκρουστούν», σε κοινωνικό και ατομικό επίπεδο, θα μπορούσαν να φρενάρουν το 40% και άνω των περιπτώσεων άνοιας; Με την υπογραφή 28 έγκριτων επιστημόνων διεθνώς, η επικαιροποιημένη μελέτη της Lancet Commission για την πρόληψη, παρέμβαση και φροντίδα της άνοιας -η οποία παρουσιάστηκε στην ετήσια Διεθνή Διάσκεψη της Διεθνούς Ομοσπονδίας Νόσου Αλτσχάιμερ- παραθέτει συνολικά 12 παράγοντες κινδύνου και προβαίνει σε...
Wed Aug 05, 2020 12:20
Ο κίνδυνος μετάδοσης του κορωνοΐού δεν σχετίζεται μόνο με την απόσταση που χωρίζει κάθε επιβάτη τρένου από συνεπιβάτη του που πάσχει από τον ιό SARS-COV-2, αλλά και από το χρονικό διάστημα της κοινής παρουσίας τους στο βαγόνι της αμαξοστοιχίας, επισημαίνουν οι ερευνητές στη σχετική μελέτη που δημοσιεύεται στο Clinical Infectious Diseases. Πρόκειται για την πρώτη μελέτη, όπως οι ίδιοι αναφέρουν, που υπολογίζει τον κίνδυνο μετάδοσης του ιού SARS-Cov-2 στα μέσα μαζικής μεταφοράς βάσει δεδομένων που...
Wed Aug 05, 2020 08:15
Επίμονα προβλήματα ακοής εξακολουθούν να ταλαιπωρούν τους αναρρώσαντες ασθενείς με κορωνοϊό σύμφωνα με βρετανούς ερευνητές. Για τους σκοπούς της μελέτης που δημοσιεύθηκε στο International Journal of Audiology, πραγματοποιήθηκε τηλεφωνική έρευνα σε 120 βρετανούς ασθενείς. Όταν οι ασθενείς ερωτήθηκαν αν είχαν παρουσιάσει αλλαγές στην ακοή τους, 13% είπαν ότι είχε επιδεινωθεί. Οκτώ ασθενείς είπαν ότι η ακοή τους είχε επιδεινωθεί και οκτώ ότι είχαν εμβοές. «Ήδη γνωρίζουμε ότι οι ιοί της ανεμοβλογιάς,της...
Wed Aug 05, 2020 07:55
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