Introduction: The incidence of oral squamous cell carcinoma (OSCC) shows a constant increase, while the long-term outcome remains poor over the last decades. Radical oxygen and nitrogen species (RONS) – initially released by carcinogens, such as alcohol and tobacco, and later maintained by the tumor microenvironment – appear to be strongly associated to chronic inflammation, tumor induction, progression, and metastatic spread. The aim of this study was to evaluate the role of oxidative and nitrosative...
Wed Aug 05, 2020 16:36
Zusammenfassung Hintergrund Unter dem Begriff Cholangiokarzinom werden diverse maligne epitheliale Neoplasien unterschiedlicher Differenzierung, Ätiologie und Pathogenese zusammengefasst. Ziel der Arbeit In dieser Arbeit sollen die Ätiologie, Pathogenese, Diagnostik, Klassifikation und molekulare Alterationen intra- und extrahepatischer Cholangiokarzinome...
Wed Aug 05, 2020 03:00
Cytological diagnosis of angiomatoid fibrous histiocytoma: Report of a case and review of literature
Abstract Angiomatoid fibrous histiocytoma (AFH) is an unusual superficially located tumor primarily affecting children and young adults. It grows slowly and most often occurs on the extremities. There is a paucity of literature on the cytological findings of AFH owing to the rarity of the lesion and its superficial location which makes it easier to perform the biopsy. Here, we present a case of AFH in a 7‐year‐old girl who presented with a left upper arm swelling. The cytology of this tumor along...
Tue Aug 04, 2020 18:09
Abstract Background Ultrasound‐guided fine‐needle aspiration biopsy (FNAB) (US‐guided FNAB) is a rapid and cost‐effective procedure for the diagnosis of breast lesions. Our Institution has a long tradition in breast FNAB performed by cytopathologists; recently we adopted both US guidance and a five‐tiered classification system similar to that proposed by the International Academy of Cytology (IAC). The aim of this study was to demonstrate the continuing role of US‐guided FNAB in the diagnosis...
Tue Aug 04, 2020 18:07
Abstract Pleural effusions can be the first manifestation, recurrence, or metastasis of small round cell sarcomas in children. The most common are Ewing sarcoma, neuroblastoma, and rhabdomyosarcoma. The cytomorphology is variable, the cells can be cohesive, single cells, small or large, morphologically mimicking lymphomas, carcinomas, melanomas, and mesothelioma depending on the sarcoma involved. Osteosarcomas are rare. Their rarity, variable histomorphologic features, immunophenotypic heterogeneity,...
Tue Aug 04, 2020 18:06
Cytologic features of angiolymphoid hyperplasia with eosinophilia: Highlighting the diagnostic clues
Abstract Angiolymphoid hyperplasia with eosinophilia (ALHE) is an uncommon, benign, inflammatory disorder involving the skin and microvasculature with an undetermined etiopathogenesis. Although the histopathology is well‐characterized, the cytologic features of this entity have been rarely described in literature. This study was conducted to describe in detail the cytomorphologic features of ALHE and to identify the characteristic features that can help in establishing a correct diagnosis of this...
Tue Aug 04, 2020 18:03
Abstract Intrathyroidal parathyroid carcinoma is an uncommon malignancy. A 46‐year‐old male presented with a left neck mass. Computed tomography (CT) scan revealed a hypodense mass in the left thyroid lobe along with evidence of metastatic lymphadenopathy. Aspiration of the left thyroid nodule was performed, and a diagnosis of malignancy was rendered, favoring a primary anaplastic carcinoma. Based on the cytologic diagnosis, the patient underwent a total thyroidectomy. Before the surgery, intact...
Tue Aug 04, 2020 17:45
Publication date: Available online 5 August 2020Source: Human PathologyAuthor(s): Ryan Sappenfield, Ivan A. Gonzalez, Dengfeng Cao, Deyali Chatterjee
Wed Aug 05, 2020 16:04
Long non‐coding RNA (lncRNA) MALAT1 has been confirmed to function as an oncogene in various solid tumors. MALAT1 level has been shown to be upregulated in relapsed acute lymphoblastic leukemia (ALL) patients, but the mechanism is unclear. This study aims to investigate the functional roles and underlying mechanisms of MALAT1 in ALL. MALAT1 and miR‐205 expression were assessed by real‐time quantitative polymerase chain reaction (RT‐qPCR). MTT assay and flow cytometry were performed to evaluate cell...
Tue Aug 04, 2020 19:55
A 78‐year‐old male was admitted to our hospital with lumbar pain and was found to have an abdominal aortic aneurysm (AAA) and femoral artery aneurysm (FAA). Initially, the patient underwent endovascular aneurysm repair (EVAR) for the AAA and aneurysmectomy for the FAA. The FAA was diagnosed by histology as immunoglobulin G4‐related disease (IgG4‐RD). The preoperative serum IgG4 level was within the normal range, although a slight serum interleukin‐6 (IL‐6) elevation was observed. Four years later,...
Tue Aug 04, 2020 13:35
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