Mutation profile of pfdhfr and pfdhps in Plasmodium falciparum among returned migrant workers in China from Africa [Epidemiology and Surveillance]

We evaluated markers of sulfadoxine-pyrimethamine (SP) resistance in P. falciparum among 254 returned migrant workers in China from Africa during 2013-2016. High prevalence of pfdhfr (97.2%) and pfdhps (96.5%) mutations were observed. The partially resistant genotype was homogeneously distributed in Africa with a modestly high prevalence (48%), whereas the super resistant genotype was only found in West Africa with a very low frequency (1.2%). The findings provided baseline data of molecular markers of SP resistance.

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