Motor dynamics underlying cargo transport by pairs of kinesin-1 and kinesin-3 motors

Intracellular cargo transport by kinesin family motor proteins is crucial for many cellular processes, particularly vesicle transport in axons and dendrites. In a number of cases, transport of specific cargo is carried out by two classes of kinesins that move at different speeds and thus compete during transport. Despite advances in single-molecule characterization and modeling approaches, many questions remain regarding the effect of inter-motor tension on motor attachment/re-attachment rates during cooperative multi-motor transport.

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