Challenges and pitfalls of investigating duodenal cancer in patients with familial adenomatous polyposis

Duodenal carcinoma is a rare manifestation of familial adenomatous polyposis (FAP). A lifetime cumulative incidence of duodenal cancer of around 4.5% (95% confidence interval, 0.1%-8.9%) was reported by the age of 57 years in the period of 1990 to 2001.1 In the meantime, however, the improved treatment of patients with FAP in general has resulted in longer life expectancy.2 Therefore, the natural course of the disease progresses further, and patients experience more-advanced stages of duodenal polyposis.

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