Correlation between serum P450arom and sex hormones in males with late-onset hypogonadism: a pilot study

OBJECTIVE: The research aimed to investigate the correlation between serum P450arom and sex hormones in males with late-onset hypogonadism (LOH).

PATIENTS AND METHODS: A total of 97 LOH patients and 301 matched healthy males of same age underwent androgen deficiency in the aging males (ADAM) and aging males' symptoms (AMS) scales as well as basic questionnaire survey. Serum P450arom, sex hormones, fasting blood glucose and lipid profiles were tested. General information, P450arom and sex hormone levels were compared between the LOH group and the control group. Pearson correlation analysis was used to analyze the correlation between serum P450arom concentration and AMS score, blood glucose, lipid profiles, body mass index (BMI) and sex hormones.

RESULTS: Compared with the control group, the fasting blood glucose, body mass index (BMI), and Estrogen/Total Testosterone ratio (E2/TT) were significantly increased in LOH group (p<0.05), while TT, E2 and testosterone secreting index (TSI) were significantly decreased (p<0.05). No significant difference in P450arom concentration was observed between the two groups (p>0.05). The serum P450arom concentration was not related to TT, E2/TT, AMS score, and BMI.

CONCLUSIONS: These findings suggested that the serum P450arom concentration is unrelated to LOH symptom score and sex hormone levels and could not be used as an observation index and diagnostic basis for LOH.

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