Plerixafor for the Treatment of WHIM Syndrome

CXC chemokine receptor 4 (CXCR4), which binds CXC chemokine ligand 12 (CXCL12), is expressed on most leukocyte subsets and regulates leukocyte development and trafficking, among other activities. In WHIM syndrome (warts, hypogammaglobulinemia, infections, and myelokathexis), autosomal dominant…

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