New insights into the pathophysiology of fasciculations in amyotrophic lateral sclerosis: an ultrasound study

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects the upper (UMN) and lower motor neurons (LMN). Fasciculations are involuntary twitches due to spontaneous contraction of muscle fascicles, originating from motor unit depolarizations as recorded by electromyography (EMG) (de Carvalho et al., 2017). Widespread fasciculations are characteristic of ALS and, therefore, have been incorporated to the diagnostic criteria (de Carvalho et al. 2008).

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