Giambra et al. show that NOTCH1 leukemias generated from fetal liver are less transplantable than those from adult bone marrow. NOTCH1 activates auto/paracrine IGF1 signaling in FL, but not BM cells, due to EZH2-dependent H3K27 trimethylation at the IGF1 promoter. This mechanism can be exploited to exhaust/deplete leukemia stem cells.
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Πέμπτη 27 Σεπτεμβρίου 2018
Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity
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Αλέξανδρος Γ. Σφακιανάκης Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,0030693260717...
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heory of COVID-19 pathogenesis Publication date: November 2020Source: Medical Hypotheses, Volume 144Author(s): Yuichiro J. Suzuki ScienceD...
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