Sedative and Anesthetic Neurotoxicity in Infants and Young Children: Not Just an Operating Room Concern

In December 2016, the US Food and Drug Administration (FDA) issued a drug safety announcement warning that repeated or lengthy (>3 hours) use of general anesthetic and sedating drugs during surgeries or procedures in children <3 years of age or in pregnant women during their third trimester may affect the development of children's brains.1 As of April 27, 2017, the FDA now requires drug manufacturers to add warning labels regarding children <3 years of age to the following general anesthetics and sedative medications: desflurane, etomidate, halothane, isoflurane, ketamine, lorazepam injection, methohexital, midazolam injection and syrup, pentobarbital, propofol, and sevoflurane.

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