Low-grade Glioma, High Stakes Controversy—When and How to Treat in the Molecular Era?

A previously healthy 43-year-old man presented with a history of 6 months of intermittent numbness and tingling in his right upper extremity and later experienced a single focal motor seizure in the same arm. Magnetic resonance imaging of the brain revealed a 5.6 × 5.5 × 6.2-cm mass in the left parietal lobe, which was T1 hypointense, T2 hyperintense, without enhancement, and with minimal surrounding edema (Fig. 1). Dexamethasone and levetiracetam were started with resolution of his symptoms and no further seizure activity.

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