Early differentiation of Dementia with Lewy bodies and Alzheimer’s disease: Heart rate variability at mild cognitive impairment stage

Dementia with Lewy bodies (DLB) is the second most common type of degenerative dementia after Alzheimer's disease (AD). Mild cognitive impairment (MCI) is well-known as a precursor of AD, but often also precedes DLB (Ferman et al., 2013; Jicha et al., 2010; McKeith et al., 2016; Yoshizawa et al., 2013). Early differentiation of DLB from AD at MCI stage is crucial for early intervention and prognosis (Bergstrom et al., 2016; Sevigny et al., 2016). However, clinical diagnosis of DLB in the early stages can be difficult because few patients display all of the core clinical features, which leads to low sensitivity of current DLB criteria (Nelson et al., 2010).

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