Toxicity, Tolerability & Compliance of Concurrent Capecitabine or 5-Fluorouracil in the Radical Management of Anal Cancer with Single-Dose Mitomycin-C and Intensity Modulated Radiation Therapy: Evaluation of a National Cohort

We present toxicity and treatment compliance data from a national cohort of patients with anal squamous cell carcinoma managed in accordance with UK guidance using intensity-modulated radiation therapy and single-dose mitomycin-C (MMC) with either 5-FU (5-fluorouracil) or capecitabine. Similar overall rates of grade 3-4 toxicity were seen with capecitabine/MMC as with 5-FU/MMC. There were, however, differences in patterns of observed haematological and non-haematological toxicities.

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