Patients affected by primary sclerosing cholangitis (PSC) have a dramatically increased risk to develop end-stage liver disease and cholangiocarcinoma. Medical treatment options for PSC are currently limited and often liver transplantation remains inevitable. This demonstrates the urgent need for novel pharmacological treatment strategies that are safe and efficient.
Bile acid (BA) sequestrants are resins that bind to BAs in the intestinal lumen, thereby decreasing their intestinal re-uptake and interrupting their enterohepatic circulation. Resins have a longstanding use in the treatment of BA-induced diarrhoea and cholestatic pruritus. However, only a very limited number of studies have so far investigated the therapeutic impact of BA sequestrants on the underlying cholestatic liver disease.
In Gut, Fuchs et al present an experimental study investigating the effects of the BA sequestrant colesevelam on cholestatic liver disease in the Mdr2–/– mouse model of sclerosing cholangitis.1 Using this model, the authors convincingly show that colesevelam efficiently treats...
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