Hypofractionated whole breast irradiation in women less than 50 years old treated on four prospective protocols

Patients less than age 50 were underrepresented in hypofractionation trials, raising concern regarding its safety and efficacy in this population. We analyzed 348 patients less than 50 treated on four prospective trials that utilized hypofractionated radiation with a concomitant boost. Local recurrence free survival was 97.7% and overall survival was 99.6% at 3 years. Clinician rated and patient reported cosmetic outcomes were collected, with the majority of patients with good or excellent cosmesis.

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