Pantoprazole pharmacokinetics in obese children: normalized to lean or ideal weight?

Shakhnovich et al report the pharmacokinetics (PK) of pantoprazole doses normalized to lean body weight (LBW) in children who are obese.1 They compared these doses with those reported in a historical group2 of children who were not obese and found the PK variables to be similar, especially for children aged ≥12 years. They concluded that LBW dosing of pantoprazole led to pantoprazole PK similar to peers who were not obese.

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