Value of ictal and interictal epileptiform discharges and high frequency oscillations for delineating the epileptogenic zone in patients with focal cortical dysplasia

Focal Cortical Dysplasia (FCD) is one of the most common etiology of medically intractable seizures in adults (Kabat and Król, 2012). Patients with this type of lesion often have drug-resistant epilepsy and become candidate for a surgical treatment. The area responsible to generate seizure, or the Epileptogenic Zone (EZ), however may be difficult to define, even in patients with identifiable lesions on MRI. Non-congruent semiology, scalp EEG and imaging findings often indicate poor localization of the EZ, and invasive EEG studies may help to define the EZ in patients with FCDs (Chassoux et al., 2000).

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