A Phase II Study of Stereotactic Body Radiotherapy and Stereotactic Body Proton Therapy for High-Risk Medically Inoperable Early-Stage Non-Small Cell Lung Cancer

A phase II randomized study to compare SBRT vs. SBPT was terminated early due to poor accrual; treatment outcomes after SBPT appeared no worse than those after SBRT numerically with low treatment related toxicity in both groups. Lack of volumetric imaging and insurance coverage for patients treated with SBPT were the major barriers to accrual. In addition to financial issues, similar maturity of treatment planning and imaged-guided delivery are essential for future comparison studies between proton and photon therapy.

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