Drug Delivery: Dimeric Drug Polymeric Micelles with Acid-Active Tumor Targeting and FRET-Traceable Drug Release (Adv. Mater. 3/2018)

In article number 1705436, Shaobing Zhou, Zi Chen, and co-workers develop an acid-active tumor-targeting nanoplatform with self-reported drug-release capability. This platform has unique features, such as a long blood circulation through shielding of the cationic charges of trans-activating transcriptional activator (TAT), an enhanced cellular internalization by regenerating the original TAT in acidic tumor tissue, and a self-reported drug release via the Förster resonance energy transfer (FRET) signal triggered by the intracellular reductant.

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