May the new suggested lower borderline limit of sweat chloride impact the diagnostic process for cystic fibrosis?

The recently published report by Farrell et al introduces some important revisions to Cystic Fibrosis Foundation Guidelines published in 2008 for screened, cystic fibrosis transmembrane conductance regulator (CFTR)–related metabolic syndrome/cystic fibrosis–screen positive, inconclusive diagnosis (CF-SPID) and nonscreened populations.1,2

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