Increased Single-Nephron GFR in Normal Adults: Too Much of a Good Thing . . . or Maybe Not?

An individual's GFR is the sum of all of his or her single nephron glomerular filtration rates (sngfrs). A recent biopsy study in kidney donors by Denic et al1 in the New England Journal of Medicine provides insights into the relationships between increased single-nephron glomerular filtration rate (sngfr), biopsy abnormalities, and certain risk factors for kidney disease.

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