Functional Outcomes after De-Escalated Chemoradiation for Human Papillomavirus-Positive Oropharyngeal Cancer: Secondary Analysis of a Phase II Trial

For patients with human papillomavirus (HPV)-associated oropharyngeal carcinoma undergoing chemoradiation with induction chemotherapy followed by de-escalated chemoradiation to 54 or 60 Gy with concurrent paclitaxel, functional outcomes, including nutritional status, gastrostomy tube use, dysphagia, and narcotic use, appear similar or favorable to historical controls treated with definitive chemoradiation to 70 Gy. These findings support ongoing efforts to evaluate de-escalated chemoradiation in patients with HPV-associated oropharyngeal carcinoma.

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