Authors’ answers on comment of Abellona et al on Metabolomic analysis for noninvasive diagnosis of hepatic fibrosis degree in patients with chronic hepatitis C

We are pleased to recognize the interest of Abellona ER et al to our study, despite its negative results. Indeed, negative studies are often neglected by the scientific community, but nevertheless may be especially useful to discuss the methodology and how to move further. More specifically one of the criticism of Abellona ER et al was regarding the originality of the study and the small sample size investigated. Indeed, we are well aware of the studies cited by colleagues with similar sample sizes [1,2].

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