Tumor control and toxicity for common SBRT dose-fractionation regimens in Stage I NSCLC

In this retrospective review of 662 T1-T3 non-small cell lung cancer lesions treated with definitive intent SBRT between 2003-2012 we found that the higher biologically equivalent SBRT dose regimen of 60 Gy in 3 fractions was associated with a statistically significant lower rate of local failure, though also slightly increased (primarily low-grade) chest wall and pulmonary toxicity. Other patterns of failure (lobar, nodal, distant) and overall survival were similar across all SBRT dose regimens.

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